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Dopaminergic Receptors Gene Expression a Molecular Marker for Major Depression and Healthy Individuals

Document Type : Original article

Authors

1 M.A of Clinical psychologist , Ardabil University of Medical Sciences, Ardabil ,Iran.

2 Associate Professor, Department of Psychology, Faculty of Humanities, University of Guilan, Guilan, Iran.

3 Assistant Professor, Department of Genetics, School of Medicine, Islamic Azad University of Ardabil, Ardabil, Iran

4 Associate Professor, Department of Counseling, Mohaghegh Ardabili University, Faculty of Educational Sciences and Psychology, Ardabil, Iran.

Abstract

Introduction: Major depression is the most common psychiatric disorder and in the world has the greatest impact of all biomedical diseases on disability. The purpose of the present study is comparing the expression of dopaminergic DRD3 and DRD4 receptors in patients with major depression and healthy Individuals. Methods: The population of this study was, all depressed patients admitted to the clinical psychologists. The method is causal-comparative study. The research sample includes of 62 depressed patients (28 male and 34 female), with the random sampling of depressed patients referred to the clinics, to be selected, and 60 healthy individuals(30 male and 30 female) as comparison group. After the informed consent.Evaluate the relative expression of gene DRD3 and DRD4, using measured by quantitative Real-Time RT-PCR and SYBER Green used. Research data was analyzed using the T-Test, SPSS and Excel software. Results: Results showed that DRD3 gene in patients compared to healthy subjects had greater relative expression(p value<0.001),but the D4 gene expression in the two groups showed no significant difference (p >0.05).The finding suggest that DRD3 gene seem to be important variables in depression, but DRD4genedoes not play a role in depression. Conclusions: The finding suggest that he DRD3 receptor gene seem to be an important variable in depression, which showed decreased expression of receptor DRD3,under the influence of this disease, which we can be used as a marker for to screen major depression disorder (MDD) correctly.

Keywords

References
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Neuropsychology
Volume 7, Issue 25 - Serial Number 25
July 2021
Pages 43-58
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